# Definition of Limit of quantitation

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**Limit of quantitation**Definition from Science & Technology Dictionaries & Glossaries

BioProcess International™ Glossary

"Quantitation limit is the lowest concentration of analyte in a sample that can be determined with acceptable precision and accuracy under the stated experimental conditions".

Copyright © 2002 - 2006, BioProcess International™. All rights reserved.General Chemistry Glossary

(LOD) The smallest detectable concentration an analytical instrument can determine at a given confidence level. IUPAC defines the quantitative detection limit as C

_{ld}= ks/m, where k is 10, s is the standard deviation of instrument readings taken on a "blank" (a solution with zero concentration of analyte), and m is the slope of a plot of instrument response vs. concentration, as calculated by linear regression.**Limit of quantitation**Definition from Encyclopedia Dictionaries & Glossaries

English Wikipedia - The Free Encyclopedia

In analytical chemistry, the

**detection limit**,**lower limit of detection**, or**LOD**(limit of detection), is the lowest quantity of a substance that can be distinguished from the absence of that substance (a*blank value*) within a stated confidence limit (generally 1%). The detection limit is estimated from the mean of the blank, the standard deviation of the blank and some confidence factor. Another consideration that affects the detection limit is the accuracy of the model used to predict concentration from the raw analytical signal.See more at Wikipedia.org... |

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