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Definition of Anergy

Babylon English

lack of energy; lack of immunity to an antigen
Anergy Definition from Language, Idioms & Slang Dictionaries & Glossaries
hEnglish - advanced version

see under anergia

WordNet 2.0

1. reduction or lack of an immune response to a specific antigen
(hypernym) immunological disorder
2. inactivity and lack of energy
(hypernym) inaction, inactivity, inactiveness
Anergy Definition from Encyclopedia Dictionaries & Glossaries
English Wikipedia - The Free Encyclopedia
Anergy is a term in immunobiology that describes a lack of reaction by the body's defense mechanisms to foreign substances, and consists of a direct induction of peripheral lymphocyte tolerance. An individual in a state of anergy often indicates that the immune system is unable to mount a normal immune response against a specific antigen, usually a self-antigen. Lymphocytes are said to be anergic when they fail to respond to their specific antigen. Anergy is one of three processes that induce tolerance, modifying the immune system to prevent self-destruction (the others being clonal deletion and immunoregulation).

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Anergy Definition from Medicine Dictionaries & Glossaries
Dictionary of Medicine (Shahram)
(i) being weak, lacking energy; (ii) lack of immunity
Lung Diseases Glossary
Absence of immune response to particular substances.
Context: Sarcoidosis
Sources: DHHS, NIH and NHLBI
CDC Tuberculosis Glossary
The inability of a person to react to skin-test antigens (even if the person is infected with the organisms tested) because of immunosuppression.
Aids Glossary
the lack of an immune response to a foreign antigen. Anergy may indicate an inability to mount a normal allergic or immune reaction, and may be a sign of immunocompromise.
Glossary of HIV/AIDS-Related Terms
1. The loss or weakening of the body's immunity to an irritating agent, or antigen<!-- (see) -->. Anergy can be thought of as the opposite of allergy, which is an overreaction to a substance. The strength of the body's immune response is often quantitatively measured by means of a skin test where a solution containing an antigen known to cause a response, such as mumps or candida, is injected immediately under the skin. Patients may be so immunologically suppressed that they are unable to produce cutaneous (skin) delayed-type hypersensitivity reaction (DTH). Such patients will usually not test positive for tuberculosis<!-- (see) --> on a tuberculin skin test (or Mantoux test). The lack of a reaction to these common antigens indicates anergy.
2. Researchers in cell culture have shown that CD4+T cells<!-- (see) --> can be turned off by a signal from HIV that leaves them unable to respond to further immune system stimulation.
HIV Vaccine Glossary
the loss or weakening of immune response to an irritating agent or antigen. Anergy can be thought of as the opposite of allergy, which is an overreaction to a substance. The strength of the immune response is often quantitatively evaluated by standardized skin tests. A small amount of solution containing an antigen known to cause a response, such as tetanus, mumps, or candida, is injected under the skin and the area checked for a localized skin reaction after 48 to 72 hours. Healthy people will develop a measurable area of redness at the injection site; people who are immune suppressed, such as people with AIDS, will have no measurable response to these skin tests.