the lack of an immune response to a foreign antigen. Anergy may indicate an inability to mount a normal allergic or immune reaction, and may be a sign of immunocompromise.
Glossary of HIV/AIDS-Related Terms
1. The loss or weakening of the body's immunity to an irritating agent, or antigen<!-- (see) -->. Anergy can be thought of as the opposite of allergy, which is an overreaction to a substance. The strength of the body's immune response is often quantitatively measured by means of a skin test where a solution containing an antigen known to cause a response, such as mumps or candida, is injected immediately under the skin. Patients may be so immunologically suppressed that they are unable to produce cutaneous (skin) delayed-type hypersensitivity reaction (DTH). Such patients will usually not test positive for tuberculosis<!-- (see) --> on a tuberculin skin test (or Mantoux test). The lack of a reaction to these common antigens indicates anergy. ATIS
2. Researchers in cell culture have shown that CD4+T cells<!-- (see) --> can be turned off by a signal from HIV that leaves them unable to respond to further immune system stimulation.
HIV Vaccine Glossary
the loss or weakening of immune response to an irritating agent or antigen. Anergy can be thought of as the opposite of allergy, which is an overreaction to a substance. The strength of the immune response is often quantitatively evaluated by standardized skin tests. A small amount of solution containing an antigen known to cause a response, such as tetanus, mumps, or candida, is injected under the skin and the area checked for a localized skin reaction after 48 to 72 hours. Healthy people will develop a measurable area of redness at the injection site; people who are immune suppressed, such as people with AIDS, will have no measurable response to these skin tests.