Definition of Ag3340
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Ag3340 Definition from Medicine Dictionaries & Glossaries
NCI Dictionary of Cancer Terms
A substance that is being studied in the treatment of cancer. It is a matrix metalloproteinase inhibitor and belongs to the family of drugs called angiogenesis inhibitors. Also called prinomastat.A Service of the National Cancer Institute.
Ag3340 Definition from Encyclopedia Dictionaries & Glossaries
English Wikipedia - The Free Encyclopedia
Prinomastat (AG-3340) is a matrix metalloprotease (MMP) inhibitor with specific selectivity for MMPs 2, 3, 9, 13, and 14. Investigations have been carried out to determine whether the inhibition of these MMPs is able to block tumour metastasis by preventing MMP degradation of the extracellular matrix proteins and angiogenesis. Prinomastat underwent a Phase III trial to investigate its effectiveness against non-small cell lung cancer (nsclc), in combination with gemcitabine chemotherapy. However, it was discovered that Prinomastat did not improve the outcome of chemotherapy in advanced Non-Small-Cell Lung Cancer.
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